Current Issue : July - September Volume : 2012 Issue Number : 3 Articles : 9 Articles
The profound use of synthetic and semi-synthetic polymers now-a-days has resulted in overlooking of natural substances that are readily available, economic, and has least adverse effects. In this research work Metroxylon sagu Rottb. and Vigna mungo Hepper are evaluated for their sustain release property by varying concentration in formulation of Diclofenac sodium. The release patterns of formulated tablets were found to be in equivalence with marketed formulation. The results of this research concluded that Metroxylon sagu Rottb. and Vigna mungo Hepper., could be better alternative for synthetic polymers....
The objective of this proof-of-concept study was to develop a platformfor controlled drug delivery based on silk fibroin (SF) and to\r\nexplore the feasibility of using SF in oral drug delivery. The SF-containing matrixes were prepared via spray-drying and film casting,\r\nand the release profile of the model drug naproxen sodium was evaluated. Attenuated total reflectance Fourier transform infrared\r\nspectroscopy (FTIR) has been used to observe conformational changes in SF- and drug-containing compositions. SF-based films,\r\nspray-dried microparticles, and matrixes loaded with naproxen were prepared. Both FTIR spectra and in vitro dissolution data\r\ndemonstrated that SF �Ÿ-sheet conformation regulates the release profile of naproxen. The controlled release characteristics of the\r\nSF-containing compositions were evaluated as a function of SF concentration, temperature, and exposure to dehydrating solvents.\r\nThe results suggest that SF may be an attractive polymer for use in controlled drug delivery systems....
Atelocollagen is a major animal protein that is used as a highly biocompatible biomaterial. To date, atelocollagen has been used\r\nas an effective drug delivery technology to sustain the release of antitumor proteins and to enhance the antitumor activity of\r\noligonucleotides in in vivo models. However, the biological effects of this technology are not fully understood. In the present\r\nstudy, we investigated the effects of atelocollagen on endothelial paracellular barrier function. An atelocollagen formulation\r\ncontaining oligonucleotides specifically increased the permeability of two types of endothelial cells, and the change was dependent\r\non the molecular size, structure of the oligonucleotides used and the concentrations of the oligonucleotide and atelocollagen in\r\nthe formulation. An immunohistochemical examination revealed that the formulation had effects on the cellular skeleton and\r\nintercellular structure although it did not affect the expression of adherens junction or tight junction proteins. These changes were\r\ninduced through p38 MAP kinase signaling. It is important to elucidate the biological functions of atelocollagen in order to be\r\nable to exploit its drug delivery properties....
The purpose of present study was to compare Kyron T-314 with other superdisintegrants and optimize the fast dissolving tablet of carbamazepine using 32 full factorial design. The amounts of disintegrant (X1) and type of disintegrant (X2) were selected as independent variables and disintegration time(DT), wetting time(WT), and time required for 80% drug release (T80%) were selected as a dependent variable. Carbamazepine fast dissolving tablets were prepared by direct compression method using different disintegrants in different amount. Microcrystalline Cellulose (MCC) used as directly compressible binder to increase the compressibility and flow of the ingredients. The tablets of all batches were evaluated for different parameters. Regression analysis and response surface analysis were performed for dependent variables. The prepared tablets were characterized by FTIR for drug excipient compatibility Studies. The optimized formulation was introduced for short term stability study. All formulation (B1-B9) had disintegration time from 20 to 40 sec and wetting time from 63 to 89 sec with sufficient mechanical strength. It was observed that amounts of disintegrant and type of disintegrant had significant influence on DT, WT and T80% (P<0.05). Formulation B3 was selected as an optimum formulation as it shows less disintegration time (20 sec) as compared to other formulation. It was concluded that Kyron T-314 is suitable for preparation of fast dissolving tablets....
Abstract: Many of the health benefits associated with aloe vera have been attributed to the polysaccharide contained in the gel of the leaves. On the other hand the important pharmaceutical applications such as the use of the dried aloe vera gel powder as an excipient in sustained release pharmaceutical dosage forms has to be explored further. The present study is development of water insoluble compound into a sustained release matrix tablets and the influence of aloe vera gel powder in the dissolution and other physical properties of the matrix tablets were assessed. The HPMC and ethyl cellulose were used as polymer and different concentration of aloe vera gel powder used as dissolution enhancer. Sustained release matrix tablets were formulated by direct compression method and subjected to various quality control studies as per the official pharmacopeial standards. The developed tablet formulation complies with the monograph. The results suggest that aloe vera is improved the dissolution of curcumin. Dissolution kinetics suggests that all the formulation followed Korsemayer Peppas model via anomalous diffusion mechanism. To conclude the aloe vera gel powder can be used as dissolution enhancer for improving the drug absorption of water insoluble drugs....
The excipients obtained from plant origin are has gained importance in formulation of various dosage forms like, emulsions, matrix tablets etc.These excipients are eco-friendly and easily available. Biopolymers are polymers that are biodegradable. The input materials for the production of these polymers may be either renewable (based on agricultural plant or animal products) or synthetic. Natural gums are widely used as emulgents, binders, suspending agents and film formers etc.These natural gums are the byproducts which results from metabolic mechanisms of plants. They are either soluble in water or forms viscous solution after absorption of water. The current study was designed to isolate, purify and characterization of biomaterial obtained from citrus maxima juice. The physical, chemical and flow properties of biomaterial obtained from citrus maxima juice were conducted and satisfactory results were obtained....
Amorphophallus Paeoniifolius found wild in the forest region, fruit are multiple seeded containing Starch. To Isolate starch pulp is removed and the macerated with water then filter. Acetone precipitation method is used to isolate starch from filtrate and dried in vacuum dryer at 400C. The physicochemical characteristic of starch has performed such as swelling index, solubility, loss on drying. This study was carried out to compare the binding effects of isolated starch with starch. Granule properties such as angle of repose, moisture content, bulk and tapped densities, Hausner’s ratio, Carr’s index and tablet properties which included weight uniformity, friability, disintegration times, and dissolution rates using standard methods. Starch of varying concentrations of 4, 6 and 8%w/w were used to produce paracetamol granules by wet granulation method....
Indian squill (Urgenia indica) is used as a cardiotonic, hair tonic and as a remedy for cancer. It has high content of mucilage which may be of pharmaceutical significance. There are many plant sourced drugs which also act as pharmaceutical adjuvants. This study was undertaken to isolate the mucilage as well as to characterize and to investigate the properties of mucilage of Urginea indica in various concentrations as disintegrant for tablet formulation containing tramadol hydrochloride as active ingredient. The mucilage from bulbs of Urginea indica was separated by an acetone precipitation method. The separated mucilage was evaluated for physicochemical characteristics such as color, solubility, swelling index, compressibility index etc. Tablets of tramadol hydrochloride were prepared by direct compression using directly compressible Avicel 102 as diluents along with different proportions of mucilage of plant Urginea indica as a disintegrant. These tablets were compared with the standard disintegrant, starch. The percentage yield of the mucilage of Urginea indica was 4%. The physicochemical parameters showed the results indicating the suitability of mucilage to be used as tablet excipient. The dissolution profile was significantly affected by the choice of the disintegrant. All formulations containing Urginea indica mucilage as disintegrant showed more than 90% drug release at 10 min whilst formulations containing starch as disintegrant showed significantly less release in this time period. Thus, this mucilage could be used as a very good natural disintegrant in comparison to costly synthetic disintegrant. A concentration of 7.5% mucilage gave the least disintegration time (20 second) compared to the starch....
Over the past decade, there has been a strong growing interest in using several forms of chitosan, more specifically nanofibers, for various biomedical applications. Chitosan has several impressive biological characteristics including but are not limited to its great biocompatibility and biodegradability, anti-bacterial properties, and cytocompatibility. In order to create nanofibers from this natural polymer, electrospinning has been widely used as the most effective technique to produce a stable structure. Overtime, a number of challenges have been overcome through the development of mechanically and structurally intact, biocompatible and multi-functional nanofibers. The recent progress of the nanofibrous structure of chitosan and their biomedical applications in tissue engineering, drug delivery, wound dressing, and antimicrobial are discussed....
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